Why is retatrutide trending now?
Retatrutide is trending because it has shown to provide more than double the weight loss and better diabetes benefits compared to Ozempic in clinical trials.
What happened
- 28 Oct 2026 06:30 UTC
Eli Lilly announced positive results from a clinical trial comparing retatrutide with Ozempic, showing greater A1C reduction and more weight loss [1][2]
What you need to know
Retatrutide is a once-weekly injection that mimics three hunger-regulating hormones: GLP-1, GIP, and glucagon.
It was shown to provide more than double the weight loss of Ozempic's highest dose in clinical trials.
Retatrutide also offers better heart benefits, including improvements in cholesterol and blood pressure.
It is expected to be submitted for FDA approval in early 2027.
The safety and long-term effects of retatrutide are not yet known, as it is not yet FDA approved.
Background
Retatrutide is a new weight loss drug developed by Eli Lilly. It mimics three hunger-regulating hormones: GLP-1, GIP, and glucagon, which are known to impact various bodily functions. In clinical trials, retatrutide showed greater weight loss and better diabetes management compared to Ozempic, another popular weight loss drug.
The TRANSCEND-T2D-2 trial, a head-to-head comparison with Ozempic, demonstrated that retatrutide provided greater A1C reduction and more substantial weight loss. Participants taking retatrutide lost an average of 44.3 to 47.4 pounds, compared to 20.9 pounds with Ozempic.
Retatrutide is expected to be submitted for FDA approval in early 2027. However, it is important to note that any version of the drug available online is from the black market and should not be consumed.
Questions people ask
Is retatrutide FDA approved?
No, retatrutide is not yet FDA approved. It is expected to be submitted for approval in early 2027.
How does retatrutide compare to Ozempic?
Retatrutide showed greater A1C reduction and more than double the weight loss compared to Ozempic in clinical trials.
What are the side effects of retatrutide?
Common side effects include diarrhea, nausea, constipation, vomiting, and dyspepsia. Most side effects are mild-to-moderate and typically resolve during treatment.
Where this came from
[1] abcnews.com
New weight loss drug retatrutide provides double the weight loss of Ozempic, Lilly says
Preview image from abcnews.com
[2] prnewswire.com
Lilly's retatrutide delivered greater A1C reduction and more than double the weight loss of Ozempic's highest approved dose in head-to-head trial
Preview image from prnewswire.com
Found through Google Trends and drafted with AI from at least two cited sources. Published automatically after passing our automated checks for sources, wording and safety. It may not have been reviewed by a person yet. Report a correction.